The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.
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The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney DiseaseRole of the Polycystins in Cell Migration, Polarity, and Tissue MorphogenesisA polycystin-centric view of cyst formation and disease: the polycystins revisitedPolycystin-1 cleavage and the regulation of transcriptional pathwaysVasopressin and disruption of calcium signalling in polycystic kidney disease.Regulation of Polycystin-1 Function by Calmodulin Binding.Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS siteDefective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.Polycystins and partners: proposed role in mechanosensitivity.Control of Adhesion GPCR Function Through Proteolytic Processing.Primary Cilia in Cystic Kidney Disease.On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.Polycystins and mechanotransduction: From physiology to disease.A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease.Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis.Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease.Acute kidney injury induces hallmarks of polycystic kidney disease.Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney.Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
P2860
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P2860
The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The γ-secretase cleavage produ ...... gh a p300-dependent mechanism.
@en
type
label
The γ-secretase cleavage produ ...... gh a p300-dependent mechanism.
@en
prefLabel
The γ-secretase cleavage produ ...... gh a p300-dependent mechanism.
@en
P2093
P2860
P1433
P1476
The γ-secretase cleavage produ ...... gh a p300-dependent mechanism.
@en
P2093
David Merrick
Hannah Chapin
John B Hogenesch
Julie E Baggs
Michael J Caplan
Stefan Somlo
Zhaoxia Sun
Zhiheng Yu
P2860
P304
P356
10.1016/J.DEVCEL.2011.10.028
P407
P577
2011-12-15T00:00:00Z