Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.

http://www.wikidata.org/entity/Q40621541

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Alzheimer mechanisms and therapeutic strategies Mechanisms of Aβ Clearance and Degradation by Glial Cells The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's disease Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value.Apolipoprotein E: from lipid transport to neurobiology Role of the APOE ε2/ε3/ε4 polymorphism in the development of primary open-angle glaucoma: evidence from a comprehensive meta-analysis.Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice Cholesterol: its regulation and role in central nervous system disorders.ApoE4 upregulates the activity of mitochondria-associated ER membranes.Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.Apolipoprotein e sets the stage: response to injury triggers neuropathology.Apolipoprotein E and cholesterol in aging and disease in the brain Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation.Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes.Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.The dark sides of amyloid in Alzheimer's disease pathogenesis.Nutritional regulation of adipose tissue apolipoprotein E expression.APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review.Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures.Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.Cultured rat cortical astrocytes synthesize melatonin: absence of a diurnal rhythm.Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease.

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Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.

http://www.wikidata.org/entity/Q40621541

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Astroglial regulation of apoli ...... tions for Alzheimer's disease.

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Astroglial regulation of apoli ...... tions for Alzheimer's disease.

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Astroglial regulation of apoli ...... tions for Alzheimer's disease.

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P2093

Faith M Harris

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Ina Tesseur

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Karin Mullendorff

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Qin Xu

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Robert W Mahley

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Shengjun Chang

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Tony Wyss-Coray

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Walter J Brecht

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Yadong Huang

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Apolipoprotein E: far more than a lipid transport protein

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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3862-3868

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10.1074/JBC.M309475200

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14585838

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Alzheimer's disease