Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.
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Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterolOxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport proteinSuppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profileHypoxia in murine atherosclerotic plaques and its adverse effects on macrophagesOSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophagesInteractions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeastOxysterols and their cellular effectors.PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivityTherapeutic approaches to drug targets in atherosclerosis.Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory responseSynthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol.Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis.Liver X receptors as integrators of metabolic and inflammatory signalingAre side-chain oxidized oxysterols regulators also in vivo?Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level.Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system.A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms.Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis.Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum.The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol effluxPrimary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis.Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα.IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride.The effect of subcutaneous methotrexate on markers of metabolic syndrome in psoriatic patients - preliminary report.
P2860
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P2860
Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Enhanced synthesis of the oxys ...... uation of foam cell formation.
@en
type
label
Enhanced synthesis of the oxys ...... uation of foam cell formation.
@en
prefLabel
Enhanced synthesis of the oxys ...... uation of foam cell formation.
@en
P2093
P1433
P1476
Enhanced synthesis of the oxys ...... uation of foam cell formation.
@en
P2093
Andrea H Rowe
Carmen A Argmann
Cynthia G Sawyez
Jane Y Edwards
Murray W Huff
Olivier H Morand
P304
P356
10.1161/01.RES.0000097606.43659.F4
P577
2003-09-25T00:00:00Z