Nuclear matrix localization and SUMO-1 modification of adenovirus type 5 E1b 55K protein are controlled by E4 Orf6 protein.
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Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption.SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PMLAdenovirus Early Proteins and Host SumoylationAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsGeneration of cell lines to complement adenovirus vectors using recombination-mediated cassette exchange.Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.HPV E6 proteins target Ubc9, the SUMO conjugating enzyme.Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodiesControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityRUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisSUMOylation affects the interferon blocking activity of the influenza A nonstructural protein NS1 without affecting its stability or cellular localization.Human pathogens and the host cell SUMOylation system.Adenovirus degradation of cellular proteins.The Human Adenovirus Type 5 L4 Promoter Is Negatively Regulated by TFII-I and L4-33K.Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression.Sp100 isoform-specific regulation of human adenovirus 5 gene expression.The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53.Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts.Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells.Adenovirus late-phase infection is controlled by a novel L4 promoter.Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Viral Interplay with the Host Sumoylation System.Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes.Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products.Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replicationAdenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression.Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells.The Mre11 Cellular Protein Is Modified by Conjugation of Both SUMO-1 and SUMO-2/3 during Adenovirus Infection
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P2860
Nuclear matrix localization and SUMO-1 modification of adenovirus type 5 E1b 55K protein are controlled by E4 Orf6 protein.
description
2003 nî lūn-bûn
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2003年の論文
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2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
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@zh-tw
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@wuu
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name
Nuclear matrix localization an ...... controlled by E4 Orf6 protein.
@en
type
label
Nuclear matrix localization an ...... controlled by E4 Orf6 protein.
@en
prefLabel
Nuclear matrix localization an ...... controlled by E4 Orf6 protein.
@en
P356
P1476
Nuclear matrix localization an ...... controlled by E4 Orf6 protein
@en
P2093
Gillian E Scott
Katherine J Lethbridge
P304
P356
10.1099/VIR.0.18820-0
P407
P577
2003-02-01T00:00:00Z