Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.
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Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donorCharacterization and evolutionary implications of the triad Asp-Xxx-Glu in group II phosphopantetheinyl transferasesStructure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesisTerminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASEStructural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic PathwaysStructure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog FoldDomain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferaseThe phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeThe Role of a Nonribosomal Peptide Synthetase in l-Lysine Lactamization During Capuramycin Biosynthesis.A 4'-phosphopantetheinyl transferase mediates non-ribosomal peptide synthetase activation in Aspergillus fumigatus.Characterization of Cfa1, a monofunctional acyl carrier protein involved in the biosynthesis of the phytotoxin coronatine.Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideumBiosynthetic gene cluster of simocyclinone, a natural multihybrid antibioticImprovement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10.Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthaseThe phosphopantetheinyl transferase superfamily: phylogenetic analysis and functional implications in cyanobacteria.Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenesFunctional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analogType I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisIdentification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthaseThe enzymology of combinatorial biosynthesis.Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases.Starter unit specificity directs genome mining of polyketide synthase pathways in fungi.Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.Type I polyketide synthases that require discrete acyltransferases.Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation NetworkRole of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway.Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis.Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrateiso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.
P2860
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P2860
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Cloning and characterization o ...... tide antitumor drug bleomycin.
@en
type
label
Cloning and characterization o ...... tide antitumor drug bleomycin.
@en
prefLabel
Cloning and characterization o ...... tide antitumor drug bleomycin.
@en
P2093
P1476
Cloning and characterization o ...... tide antitumor drug bleomycin.
@en
P2093
P304
P356
10.1016/S1074-5521(01)00047-3
P577
2001-07-01T00:00:00Z