Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. - Wikidata - awgldk - TriplyDB

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.

http://www.wikidata.org/entity/Q40702649

about

CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1 Mammalian target of rapamycin: a central node of complex signaling cascades Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia Novel therapeutic strategies for multiple myeloma The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia Targeting NF-kappaB in Waldenstrom macroglobulinemia Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis Inhibition of IGF-1 signalling enhances the apoptotic effect of AS602868, an IKK2 inhibitor, in multiple myeloma cell lines.Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma.Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia.TAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies.Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia.MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242 Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies.Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia.Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone.Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death.Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells.The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro.New insights, recent advances, and current challenges in the biological treatment of multiple myeloma.The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers.Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.The use of novel agents in the treatment of relapsed and refractory multiple myeloma Survival and proliferation factors of normal and malignant plasma cells.Activity of everolimus (RAD001) in relapsed and/or refractory multiple myeloma: a phase I study.Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell lines The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.Skp2 is a promising therapeutic target in breast cancer.SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo.Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue.Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma.Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways.

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.

http://www.wikidata.org/entity/Q40702649

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2002 nî lūn-bûn

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name

Role of the phosphatidylinosit ...... apoptosis in multiple myeloma.

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Role of the phosphatidylinosit ...... apoptosis in multiple myeloma.

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Role of the phosphatidylinosit ...... apoptosis in multiple myeloma.

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Role of the phosphatidylinosit ...... apoptosis in multiple myeloma.

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Catherine Lacombe

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Didier Bouscary

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Franck Viguié

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François Dreyfus

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Frédéric Pene

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Odile Muller

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Patrick Mayeux

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Yann-Erick Claessens

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Phosphorylation and activation of p70s6k by PDK1

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Role of the F-box protein Skp2 in lymphomagenesis

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

beta-catenin signaling and cancer

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

Regulation of cell death protease caspase-9 by phosphorylation

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10.1038/SJ.ONC.1205923

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