Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
about
Recent advances toward a molecular mechanism of efflux pump inhibitionMultiple Drug Transport Pathways through Human P-Glycoprotein.Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoproteinPredicting binding to p-glycoprotein by flexible receptor dockingMultiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutantsMolecular models of human P-glycoprotein in two different catalytic statesPKC expression is regulated by dietary K intake and mediates internalization of SK channels in the CCD.Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects.ROMK1 channel activity is regulated by monoubiquitinationIn vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosinHeterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.Protein contacts and ligand binding in the inward-facing model of human P-glycoprotein.Interactions of the multidrug resistance modulators tariquidar and elacridar and their analogues with P-glycoprotein.Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoproteinStructure and function of efflux pumps that confer resistance to drugsIdentification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence.Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.Insight in eukaryotic ABC transporter function by mutation analysis.Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)Transporters in the intestine limiting drug and toxin absorption.Natural and synthetic polymers as inhibitors of drug efflux pumps.Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD.Binding site of ABC transporter homology models confirmed by ABCB1 crystal structureIn silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1.Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).ABC proteins protect the human body and maintain optimal health.New-generation efflux pump inhibitors.The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein--a well-known, yet poorly understood drug transporter.Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.Impact of the Recent Mouse P-Glycoprotein Structure for Structure-Based Ligand Design.Toward a unifying strategy for the structure-based prediction of toxicological endpoints.
P2860
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P2860
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
@en
type
label
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
@en
prefLabel
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.
@en
P2860
P356
P1476
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein
@en
P2093
David M Clarke
P2860
P304
44332-44338
P356
10.1074/JBC.M208433200
P407
P50
P577
2002-09-09T00:00:00Z