Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. - Wikidata - awgldk - TriplyDB

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

http://www.wikidata.org/entity/Q40706999

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MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells SW-620 cells treated with topoisomerase I inhibitor SN-38: gene expression profiling Implications of mismatch repair-deficient status on management of early stage colorectal cancer EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies Microsatellite instability in colorectal cancer-the stable evidence.Genetic pathways, prevention, and treatment of sporadic colorectal cancer Deciphering cellular states of innate tumor drug responses.Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications.Antitumour activity of XR5944 in vitro and in vivo in combination with 5-fluorouracil and irinotecan in colon cancer cell lines Chemotherapeutic implications in microsatellite unstable colorectal cancer.Molecular markers of chemotherapeutic response and toxicity in colorectal cancer.Molecular dissection of microsatellite instable colorectal cancer Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.Deficient mismatch repair system in patients with sporadic advanced colorectal cancer Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy.Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer.Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism.Chemoprevention, chemotherapy, and chemoresistance in colorectal cancer.Chemotherapy of MMR-deficient colorectal cancer.Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells.Involvement of Non-coding RNAs in Chemo- and Radioresistance of Colorectal Cancer.hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases.Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.Alteration of Drug Sensitivity in Human Colon Cancer Cells after Exposure to Heat: Implications for Liver Metastasis Therapy using RFA and Chemotherapy.Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38.Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy.Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer.

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P2860

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

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name

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

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Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

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Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

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International Journal of Cancer

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Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

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P2093

C Richard Boland

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Christoph Hanski

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Hans Scherübl

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Mandar R Bhonde

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Marie-Luise Hanski

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Martin Zeitz

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Michael Notter

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Roberta Magrini

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P2860

Mechanisms of G2 arrest in response to overexpression of p53

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Irinotecan in the treatment of colorectal cancer: clinical overview.

The "comparative growth assay": examining the interplay of anti-cancer agents with cells carrying single gene alterations.

Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors

Determinants of CPT-11 and SN-38 activities in human lung cancer cells

Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status.

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

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10.1002/IJC.10565

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1

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101

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11178619

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