Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.
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MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityReview of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramificationsMicrosatellite instability in colorectal cancerLynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancerThe path for metal complexes to a DNA targetRole of Deficient Mismatch Repair in the Personalized Management of Colorectal CancerInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchThe absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutationAn unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency.A monofunctional platinum complex coordinated to a rhodium metalloinsertor selectively binds mismatched DNA in the minor groove.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedsideGenomic and epigenetic instability in colorectal cancer pathogenesis.Clement Richard Boland, Jr., MD: a conversation with the editor. Interview by William Clifford RobertsMismatch repair in correction of replication errors and processing of DNA damage.The deprivation syndrome is the driving force of phylogeny, ontogeny and oncogeny.Systemic treatment of advanced colorectal cancer: tailoring therapy to the tumor.The "comparative growth assay": examining the interplay of anti-cancer agents with cells carrying single gene alterations.Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.Mismatch repair proficiency and in vitro response to 5-fluorouracil.N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications.Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatinChemotherapeutic implications in microsatellite unstable colorectal cancer.The history of Lynch syndrome.Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localizationGRG Profiles: John M. Carethers.Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.HEREDITARY, SPORADIC AND METASTATIC COLORECTAL CANCER ARE COMMONLY DRIVEN BY SPECIFIC SPECTRUMS OF DEFECTIVE DNA MISMATCH REPAIR COMPONENTS.DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.The colorectal cancer immune microenvironment and approach to immunotherapies.Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells.Cyclin E and histone H3 levels are regulated by 5-fluorouracil in a DNA mismatch repair-dependent manner.MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines.Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.Growth inhibition due to complementation of transforming growth factor-beta receptor type II-defect by human chromosome 3 transfer in human colorectal carcinoma cells.Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage.Proteomics, genomics, and molecular biology in the personalized treatment of colorectal cancer.
P2860
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P2860
Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@en
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@nl
type
label
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@en
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@nl
prefLabel
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@en
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@nl
P2093
P2860
P356
P1476
Competency in mismatch repair ...... l-N'-nitro-N-nitrosoguanidine.
@en
P2093
C R Boland
D P Chauhan
J M Carethers
P2860
P304
P356
10.1172/JCI118767
P407
P577
1996-07-01T00:00:00Z