Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
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Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceReplication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression.Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAsSelection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C VirusReplication Studies Using Genotype 1a Subgenomic Hepatitis C Virus RepliconsCrystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase EnzymeMolecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase InhibitorHepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In VitroSynergy of Small Molecular Inhibitors of Hepatitis C Virus Replication Directed at Multiple Viral TargetsBinding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase InhibitorsSynergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase InhibitorsInhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected CellsStructure-function relationships among RNA-dependent RNA polymerasesComparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase InhibitorsMolecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine InhibitorSelected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R14791,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside InhibitorsRobust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected ChimpanzeesConsensus siRNA for inhibition of HCV genotype-4 replicationThe Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A RepliconsSlow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C VirusMK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A ProteaseMechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C VirusInhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral interventionA cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5APromising candidates for the treatment of chronic hepatitis C.Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranesCharacterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.A highly sensitive and selective viral protein detection method based on RNA oligonucleotide nanoparticle.High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitorsMolecular model of SARS coronavirus polymerase: implications for biochemical functions and drug designCross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb bindersHepatitis C virus therapies: current treatments, targets and future perspectives.Structure-based design of hepatitis C virus inhibitors.Repurposing of rutin for the inhibition of norovirus replication.Recent developments in target identification against hepatitis C virus.
P2860
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P2860
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Identification and biological ...... RNA-dependent RNA polymerase.
@en
type
label
Identification and biological ...... RNA-dependent RNA polymerase.
@en
prefLabel
Identification and biological ...... RNA-dependent RNA polymerase.
@en
P2093
P2860
P356
P1476
Identification and biological ...... RNA-dependent RNA polymerase.
@en
P2093
Adam T Gates
Alfred DelVecchio
Antony N Shaw
Arun Kaura
Audrey Baker
Carol Silverman
Cathy Greenwood
Dashyant Dhanak
David J Casper
P2860
P304
38322-38327
P356
10.1074/JBC.M205566200
P407
P577
2002-08-06T00:00:00Z