Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
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Porcine islet amyloid polypeptide fragments are refractory to amyloid formationA hIAPP-derived all-D-amino-acid inhibits hIAPP fibrillation efficiently at membrane surface by targeting α-helical oligomeric intermediatesBisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetesTetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic miceAmyloidogenesis abolished by proline substitutions but enhanced by lipid binding.Selection for nonamyloidogenic mutants of islet amyloid polypeptide (IAPP) identifies an extended region for amyloidogenicity.Non-esterified fatty acids generate distinct low-molecular weight amyloid-β (Aβ42) oligomers along pathway different from fibril formationThe mechanism of enhanced insulin amyloid fibril formation by NaCl is better explained by a conformational change modelDesign of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesisInhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Phenol red interacts with the protofibril-like oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts.Short Peptides as Inhibitors of Amyloid AggregationMatrix Metalloproteinase-9 Protects Islets from Amyloid-induced ToxicityRational design of potent domain antibody inhibitors of amyloid fibril assembly.Mechanism of Inhibition of Human Islet Amyloid Polypeptide-Induced Membrane Damage by a Small Organic Fluorogen.Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization.Electrochemical Assay of Human Islet Amyloid Polypeptide and Its AggregationMolecular understanding of a potential functional link between antimicrobial and amyloid peptides.Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes.Inhibition of human amylin fibril formation by insulin-mimetic vanadium complexes.Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptide and protects pancreatic beta-cells against cytotoxicity.Amylin uncovered: a review on the polypeptide responsible for type II diabetes.Micelle formation by a fragment of human islet amyloid polypeptide.Novel insights into amylin aggregation.Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.Inhibition of peptide aggregation by means of enzymatic phosphorylation.Stimulation of insulin fibrillation by urea-induced intermediates.A direct fluorescence-based technique for cellular localization of amylin.Human Islet Amyloid Polypeptide N-Terminus Fragment Self-Assembly: Effect of Conserved Disulfide Bond on Aggregation Propensity.Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation.Design and study of lipopeptide inhibitors on preventing aggregation of human islet amyloid polypeptide residues 11-20.Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes.Dual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide.Are fibrilgrowth and membrane damage linked processes? An experimental and computational study of IAPP12–18and IAPP21–27peptides
P2860
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P2860
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
@en
type
label
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
@en
prefLabel
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
@en
P2093
P1476
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.
@en
P2093
Audrey A Darabie
JoAnne McLaurin
Louise A Scrocchi
Paul E Fraser
Sindy Cheung
Stefko Waschuk
P304
P356
10.1016/S0022-2836(02)00164-X
P407
P577
2002-05-01T00:00:00Z