Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.
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Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrinTargeting leukocyte integrins in human diseasesStructural basis of integrin regulation and signalingSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamA small molecule agonist of an integrin, alphaLbeta2.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bondsA simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparinFRET detection of lymphocyte function-associated antigen-1 conformational extension.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateThe C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsAlpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injuryIntegrin antagonists as therapeutics for inflammatory diseases.Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletionsIntersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.Solution structure of a novel T-cell adhesion inhibitor derived from the fragment of ICAM-1 receptor: cyclo(1,8)-Cys-Pro-Arg-Gly-Gly-Ser-Val-Cys.The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activationIntegrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response.A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon.Lymphocyte function antigen-1 mediates leukocyte adhesion and subsequent liver damage in endotoxemic miceCompetition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood.Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.Leukocyte function-associated antigen 1-mediated adhesion stability is dynamically regulated through affinity and valency during bond formation with intercellular adhesion molecule-1.
P2860
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P2860
Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Small molecule inhibitors indu ...... ghts into integrin inhibition.
@en
type
label
Small molecule inhibitors indu ...... ghts into integrin inhibition.
@en
prefLabel
Small molecule inhibitors indu ...... ghts into integrin inhibition.
@en
P2093
P2860
P356
P1476
Small molecule inhibitors indu ...... ghts into integrin inhibition.
@en
P2093
Gabriele Weitz-Schmidt
Karl Welzenbach
Ulrich Hommel
P2860
P304
10590-10598
P356
10.1074/JBC.M110521200
P407
P577
2002-01-07T00:00:00Z