Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
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The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsGPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein SignalingA beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.Beyond desensitization: physiological relevance of arrestin-dependent signaling.Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor.Retromer terminates the generation of cAMP by internalized PTH receptors.Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Endosomal generation of cAMP in GPCR signaling.Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting.Molecular and cellular mechanisms of the anabolic effect of intermittent PTHNon-canonical signaling of the PTH receptorNa/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway.Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complexMolecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTHTherapeutic potential of β-arrestin- and G protein-biased agonists.β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivoProlonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling.TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review).Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking.Gastric acid, calcium absorption, and their impact on bone health.The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction.PTH and Vitamin D.PTH regulates β2-adrenergic receptor expression in osteoblast-like MC3T3-E1 cells.Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypesTranslating in vitro ligand bias into in vivo efficacy.Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signalingNHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G.Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling.Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor.Updated Insight into the Physiological and Pathological Roles of the Retromer Complex.Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50).NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling.
P2860
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P2860
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Internalization determinants o ...... arrestin/receptor association.
@en
type
label
Internalization determinants o ...... arrestin/receptor association.
@en
prefLabel
Internalization determinants o ...... arrestin/receptor association.
@en
P2093
P2860
P356
P1476
Internalization determinants o ...... arrestin/receptor association.
@en
P2093
Cornelius Krasel
Robert A Nissenson
Stéphanie Chauvin
Tom Bambino
P2860
P304
P356
10.1074/JBC.M110433200
P407
P577
2001-11-28T00:00:00Z