Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.
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A membrane protein required for dislocation of misfolded proteins from the ERThe TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ERDeubiquitinases sharpen substrate discrimination during membrane protein degradation from the ERA glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.Recent technical developments in the study of ER-associated degradationThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologySignal peptide peptidase is required for dislocation from the endoplasmic reticulumPlasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products.Human cytomegalovirus US3 chimeras containing US2 cytosolic residues acquire major histocompatibility class I and II protein degradation properties.Lessons from viral manipulation of protein disposal pathwaysBinding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.HCMV infection: modulating the cell cycle and cell death.Human cytomegalovirus US2 causes similar effects on both major histocompatibility complex class I and II proteins in epithelial and glial cellsDislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayerA viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells.SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteinsA bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoproteinPathogen evasion strategies for the major histocompatibility complex class I assembly pathway.The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex.Equine herpesvirus type 4 UL56 and UL49.5 proteins downregulate cell surface major histocompatibility complex class I expression independently of each other.The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins.A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules.Feeling manipulated: cytomegalovirus immune manipulation.Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation.Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides.US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide
P2860
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P2860
Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
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2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
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2001年學術文章
@zh-hant
name
Membrane-specific, host-derive ...... ity complex class I molecules.
@en
type
label
Membrane-specific, host-derive ...... ity complex class I molecules.
@en
prefLabel
Membrane-specific, host-derive ...... ity complex class I molecules.
@en
P2860
P356
P1476
Membrane-specific, host-derive ...... ity complex class I molecules.
@en
P2093
Hidde L Ploegh
Margo H Furman
P2860
P304
P356
10.1074/JBC.M109765200
P407
P577
2001-11-20T00:00:00Z