Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
about
Epigenetics and agingSirtuin functions and modulation: from chemistry to the clinicDiabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum ConceptSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsSynthesis and Assay of SIRT1-Activating CompoundsStructural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 InhibitorUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.A molecular imaging biosensor detects in vivo protein folding and misfolding.SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent PathwayEmerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Targeting histone methylation for colorectal cancerChemical and structural biology of protein lysine deacetylasesSIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context.Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Biophysical characterization of hit compounds for mechanism-based enzyme activation.Structural Basis of Sirtuin 6 Activation by Synthetic Small MoleculesMetformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
P2860
Q26740029-26B496EE-F601-46B3-9B08-AC6D1B474F18Q26745884-D4C5B09A-5F1C-44C2-A82D-35DF2AA97A9EQ26749486-E8B32CCF-D379-41EC-AD67-58D88D51C449Q28079390-BEB48FC2-C152-4504-8192-DA5F381F1080Q28314993-2401582F-CE4A-4AD1-BE35-75657BC3CD5FQ28818352-B1069B3E-583F-46F6-A610-A21A3EBF62D5Q30313597-1A889BBB-4E24-4436-9DF3-6F3C67908573Q30830222-37769135-913E-4122-9B91-7935863985F0Q33603608-CA3760CF-D191-42B2-A3A7-1EA85E967763Q33715990-8DD6F0C5-8F5A-4BAC-AFDC-F7FA38899724Q35960986-E31CB3B4-96D6-4D9B-8B15-EB79A1E3C9B2Q35967457-362EEEE3-C56D-4A1C-A62D-1F7F0770AC67Q36045518-B110DDC0-70C9-4958-BB13-671CCF799FC9Q36901972-56C4BD8A-3439-49D7-8F2E-C2953A1E7C97Q38912441-8EE5BBAA-14CD-4569-A830-B69110B682C5Q39091771-243D923C-2168-489C-888D-812E14596C55Q39175486-872D4CE8-337B-4979-89AB-C4CE6AC73647Q39299912-E23E4735-F117-486A-92BE-1C2D7D996550Q40803150-FD0AC922-B0B0-43D5-8E96-B70D9B931B0DQ41264744-CDA9EB4B-1C42-4FDF-837F-C8F635930321Q46353864-51468C2F-4A31-45FF-9F87-C2E5287E56C5Q47996927-8B8E705A-3B7B-497F-B442-A47182C35252Q52652199-2D5BD1DD-81B5-4BB2-90AA-27DA3295F5E7Q56925925-F18054D1-8811-470D-9874-F5DF5A1A389DQ59136454-F5FF1F36-EA4D-4FAA-AB8E-E8134E5FD00A
P2860
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
@en
type
label
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
@en
prefLabel
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
@en
P2093
P2860
P50
P356
P1476
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
@en
P2093
April W Case
Benjamin Schwartz
Beth Pietrak
Brian H White
Bruce Szczepankiewicz
Charles A Blum
Cheney Mao
Christopher Oalmann
Dongming Qian
P2860
P2888
P356
10.1038/NCOMMS8645
P407
P577
2015-07-02T00:00:00Z
P5875
P6179
1041102854