Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. - Wikidata - awgldk - TriplyDB

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

http://www.wikidata.org/entity/Q40777946

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TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu Retroviral transduction of peptide stimulated t cells can generate dual t cell receptor-expressing (bifunctional) t cells reactive with two defined antigens T cell avidity and tumor recognition: implications and therapeutic strategies.Adoptive T-cell therapy for Leukemia Genetically modified T cells in cancer therapy: opportunities and challenges Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction Technical Considerations for the Generation of Adoptively Transferred T Cells in Cancer Immunotherapy T-cell receptor gene therapy--ready to go viral?How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma T-Cell Receptor-Engineered Cells for the Treatment of Hematologic Malignancies.Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer.Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha.T cell receptor-transgenic primary T cells as a tool for discovery of leukaemia-associated antigens.A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function Selection of human antibody fragments directed against tumor T-cell epitopes for adoptive T-cell therapy.Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity.A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection.Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells.Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells.Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia.Immunotherapy of human cancers using gene modified T lymphocytes.Clinical application of genetically modified T cells in cancer therapy.Current status of adoptive immunotherapy of malignancies.Redirecting cytotoxic T lymphocyte responses with T-cell receptor transgenes.T-cell therapy of leukemia.T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.Genetically engineered T cells for the treatment of cancer.Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions.A sense of tumour for the immune system.Adoptive cellular therapy: a therapeutic reality?CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor High-throughput identification of antigen-specific TCRs by TCR gene capture.Targeting tumours with genetically enhanced T lymphocytes.Prospects for immunotherapy of malignant disease.Redirecting T lymphocyte specificity using T cell receptor genes.Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation.Identification of NY-BR-1-specific CD4(+) T cell epitopes using HLA-transgenic mice.Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

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P2860

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

http://www.wikidata.org/entity/Q40777946

description

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

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Nature Immunology

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

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P2093

C Huber

http://www.w3.org/2001/XMLSchema#string

C J Melief

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C Lotz

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E Sadovnikova

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H J Stauss

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J Kuball

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M Theobald

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R A Willemsen

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R H Voss

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R L Bolhuis

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P2860

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

Two new proteases in the MHC class I processing pathway

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

A new era for cancer immunotherapy based on the genes that encode cancer antigens

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Amplification of a gene encoding a p53-associated protein in human sarcomas

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

Changing T cell specificity by retroviral T cell receptor display.

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

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962-970

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10.1038/NI1001-962

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10

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2

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11577350

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