Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
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Biological sex and mechanisms of ischemic brain injuryMolecular mechanisms in the pathogenesis and treatment of acute ischemic strokeHuman T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke.Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.Organotypic Hippocampal Slices as Models for Stroke and Traumatic Brain InjuryBlockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retinaPARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner.Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase.3-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury.Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cellsPARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.The Sound of Silence: RNAi in Poly (ADP-Ribose) ResearchTherapeutic potential of PARP inhibitors for metastatic breast cancer.Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities.Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling.Differentiated NSC-34 cells as an in vitro cell model for VX.Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia.HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling pathway.Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in ratsPoly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice.Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors.Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.Protein kinase C-mediated necrosis-apoptosis switch of cortical neurons by conditioned medium factors secreted under the serum-free stress.Deleterious activation of poly(ADP-ribose)polymerase-1 in brain after in vivo oxidative stress.Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia.Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury.Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction.PARP Inhibition Prevents Ethanol-Induced Neuroinflammatory Signaling and Neurodegeneration in Rat Adult-Age Brain Slice Cultures.Dexpramipexole improves bioenergetics and outcome in experimental stroke.Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia.Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
P2860
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P2860
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Poly(ADP-ribose) polymerase in ...... l models of cerebral ischemia.
@en
type
label
Poly(ADP-ribose) polymerase in ...... l models of cerebral ischemia.
@en
prefLabel
Poly(ADP-ribose) polymerase in ...... l models of cerebral ischemia.
@en
P2093
P356
P1476
Poly(ADP-ribose) polymerase in ...... l models of cerebral ischemia.
@en
P2093
Chiarugi A
Pellegrini-Giampietro DE
Pellicciari R
Peruginelli F
Romagnoli P
P2888
P304
P356
10.1038/SJ.CDD.4400884
P577
2001-09-01T00:00:00Z
P5875
P6179
1038475258