Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.
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Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene.Mammalian Krüppel-like factors in health and diseasesThe diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiologyTranscriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiationOverexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecityGastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycleThe Krüppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferationHaploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesisp21 in cancer: intricate networks and multiple activitiesTopoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex.KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma.KLF16 promotes proliferation in gastric cancer cells via regulating p21 and CDK4.Overexpression of KLF13 and FGFR3 in oral cancer cells.Regulation of EMT by KLF4 in gastrointestinal cancer.TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regionsThe zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene.Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancerKrüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity.Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer.Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity.Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membraneKrüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damageKLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling.Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular developmentTranscriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition.The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damageCDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.The Pathobiology of Krüppel-like Factors in Colorectal Cancer.KLF4 regulation in intestinal epithelial cell maturationRoles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.
P2860
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P2860
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Expression of the gut-enriched ...... line RKO is dependent on CDX2.
@en
type
label
Expression of the gut-enriched ...... line RKO is dependent on CDX2.
@en
prefLabel
Expression of the gut-enriched ...... line RKO is dependent on CDX2.
@en
P2093
P2860
P356
P1433
P1476
Expression of the gut-enriched ...... line RKO is dependent on CDX2.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204645
P407
P577
2001-08-01T00:00:00Z
P5875
P6179
1053104099