Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
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Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1A novel role of Sprouty 2 in regulating cellular apoptosisTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionDistinct requirements for the Sprouty domain for functional activity of Spred proteinsThe bimodal regulation of epidermal growth factor signaling by human Sprouty proteinsSprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activationExpression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational controlErbin suppresses the MAP kinase pathwayA functional interaction between sprouty proteins and caveolin-1The NPAS3 gene--emerging evidence for a role in psychiatric illnessSTAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifSystematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.Regulation of sprouty stability by Mnk1-dependent phosphorylation.Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression.The VASP-Spred-Sprouty domain puzzle.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopSprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoidsThe developing story of Sprouty and cancer.The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in miceSprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapyFunctional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2.The MAPK pathway as an apoptosis enhancer in melanoma.Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGFShp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty.The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.Gene disruption of Spred-2 causes dwarfism.The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cellsSprouty2 downregulates angiogenesis during mouse skin wound healing.Expression and functional role of sprouty-2 in breast morphogenesis.Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Activation of unfolded protein response in transgenic mouse lenses.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing FieldIdentification of a new Sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproductionSprouty2 mediated tuning of signalling is essential for somite myogenesis.
P2860
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P2860
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Identification of a dominant n ...... factor-induced ERK activation.
@en
type
label
Identification of a dominant n ...... factor-induced ERK activation.
@en
prefLabel
Identification of a dominant n ...... factor-induced ERK activation.
@en
P2093
P2860
P356
P1476
Identification of a dominant n ...... factor-induced ERK activation.
@en
P2093
P2860
P304
36804-36808
P356
10.1074/JBC.C100386200
P407
P577
2001-08-08T00:00:00Z