Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
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Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.The amyloid-beta precursor protein: integrating structure with biological functionNMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's diseaseDissecting Alzheimer disease in Down syndrome using mouse modelsOn cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)Genetic variants associated with neurodegenerative Alzheimer disease in natural modelsConstitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloproteasePresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyThe Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylationA functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationMicrotubule-dependent recruitment of Staufen-green fluorescent protein into large RNA-containing granules and subsequent dendritic transport in living hippocampal neuronsCOL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice.Versatile somatic gene transfer for modeling neurodegenerative diseases.New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's diseaseThe Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic micePresenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexRodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice.Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.Large scale transient 5-HT3 receptor production with the Semliki Forest Virus Expression System.The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and micePost-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP.Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodiesExpression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic miceRole of Species-Specific Primary Structure Differences in Aβ42 Assembly and NeurotoxicityBrain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains.The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.APP mouse models for Alzheimer's disease preclinical studies.Protein kinase C-regulated aβ production and clearance.The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.Neuronal membrane cholesterol loss enhances amyloid peptide generation.Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neuronsFamilial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
P2860
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P2860
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Production of intracellular am ...... utions in the rodent sequence.
@en
type
label
Production of intracellular am ...... utions in the rodent sequence.
@en
prefLabel
Production of intracellular am ...... utions in the rodent sequence.
@en
P2093
P2860
P1433
P1476
Production of intracellular am ...... utions in the rodent sequence.
@en
P2093
B De Strooper
F Van Leuven
G Multhaup
K Beyreuther
P2860
P304
P407
P577
1995-10-01T00:00:00Z