Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
about
Genomic views of STAT function in CD4+ T helper cell differentiationA natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunityMedical case reports in the age of genomic medicineSevere infectious diseases of childhood as monogenic inborn errors of immunityInborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypesSTAT3 and the Hyper-IgE syndrome: Clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertaintiesMendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunityDiscovery of single-gene inborn errors of immunity by next generation sequencingRecent molecular insights into rickettsial pathogenesis and immunity'"Why me, why now?" Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infectionGenetics of susceptibility to human infectious diseaseHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeIL-12Rβ1 deficiency in two of fifty children with severe tuberculosis from Iran, Morocco, and TurkeyGenetic susceptibility to tuberculosis.The TB pandemic: an old problem seeking new solutions.A novel form of cell type-specific partial IFN-gammaR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon.Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma.Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease.Innate defects of the IL-12/IFN-γ axis in susceptibility to infections by mycobacteria and salmonellaB cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.CD36 deficiency attenuates experimental mycobacterial infection.A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.Cellular and Molecular Defects Underlying Invasive Fungal Infections-Revelations from Endemic Mycoses.A novel STAT1 mutation associated with disseminated mycobacterial disease.Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptorsSTAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis.Gamma interferon is dispensable for neopterin production in vivoLoss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.Chemoattraction of macrophages by secretory molecules derived from cells expressing the signal peptide of eosinophil cationic proteinSTAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous systemSevere Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1A novel form of human STAT1 deficiency impairing early but not late responses to interferons.Cytokines and immunodeficiency diseases.A novel homozygous p.R1105X mutation of the AP4E1 gene in twins with hereditary spastic paraplegia and mycobacterial disease.Stat proteins and oncogenesis.Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.IFNs and STATs in innate immunity to microorganisms.Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients.Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression.
P2860
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P2860
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
@en
type
label
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
@en
prefLabel
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
@en
P2093
P356
P1433
P1476
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
@en
P2093
C Dargemont
N Thomassin
R D Schreiber
S M Holland
S Rosenzweig
P304
P356
10.1126/SCIENCE.1061154
P407
P577
2001-07-01T00:00:00Z