Rational design of a receptor super-antagonist of human interleukin-6.
about
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signalingPotential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancerSTAT signaling in the pathogenesis and treatment of cancerHuman herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6.Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.Receptor recognition by gp130 cytokines.Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130
P2860
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P2860
Rational design of a receptor super-antagonist of human interleukin-6.
description
1994 nî lūn-bûn
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1994年の論文
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1994年学术文章
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1994年学术文章
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1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
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1994年學術文章
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name
Rational design of a receptor super-antagonist of human interleukin-6.
@en
type
label
Rational design of a receptor super-antagonist of human interleukin-6.
@en
prefLabel
Rational design of a receptor super-antagonist of human interleukin-6.
@en
P2093
P2860
P1433
P1476
Rational design of a receptor super-antagonist of human interleukin-6.
@en
P2093
Altamura S
Ciapponi L
Delmastro P
Demartis A
Toniatti C
P2860
P304
P407
P577
1994-12-01T00:00:00Z