1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
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Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signalingThe structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayCrystal structure of a cytokine-binding region of gp130.Cloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAsConservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic InterventionCrystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid LigandDiscovery and characterization of olokizumabThe structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6The crystal structure of human interferon beta at 2.2-A resolutionSolution structure of leukemia inhibitory factorIdentification of three distinct receptor binding sites of murine interleukin-11Inflammation and Alzheimer's diseaseInterleukin-11 signals through the formation of a hexameric receptor complexDefinition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesisDirect determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopyFunction and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligandsStructure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound databaseReceptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.IL-6 type cytokine receptor complexes: hexamer, tetramer or both?Receptor recognition by gp130 cytokines.Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases.Chemical neuroimmunology: health in a nutshell bidirectional communication between immune and stress (limbic-hypothalamic-pituitary-adrenal) systems.Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance.Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.Nitric oxide and thiol redox regulation of Janus kinase activityConsequences of regulated pre-mRNA splicing in the immune system.Interleukin-6: structure-function relationships.N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6The role of interleukin-6 in insulin resistance, body fat distribution and energy balance.Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms.Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation.Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor.Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.Probing binding mechanism of interleukin-6 and olokizumab: in silico design of potential lead antibodies for autoimmune and inflammatory diseases.Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions.Limbal epithelial stem-microenvironmental alteration leads to pterygium development.Roles of IL-6 in Ocular Inflammation: A Review.
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P2860
1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
1.9 A crystal structure of int ...... or dimerization and signaling.
@en
1.9 A crystal structure of int ...... or dimerization and signaling.
@nl
type
label
1.9 A crystal structure of int ...... or dimerization and signaling.
@en
1.9 A crystal structure of int ...... or dimerization and signaling.
@nl
prefLabel
1.9 A crystal structure of int ...... or dimerization and signaling.
@en
1.9 A crystal structure of int ...... or dimerization and signaling.
@nl
P2093
P2860
P356
P1433
P1476
1.9 A crystal structure of int ...... or dimerization and signaling.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.5.989
P407
P577
1997-03-01T00:00:00Z