Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

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http://www.wikidata.org/entity/Q40796761

Q40796761

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Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene Chromosome 21 and down syndrome: from genomics to pathophysiology LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression.The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice miR-33 links SREBP-2 induction to repression of sterol transporters.Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.High-density lipoprotein and atherosclerosis: Roles of lipid transporters.ABCA1: regulation, trafficking and association with heteromeric proteins.Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis.Regulation of ABCA1 functions by signaling pathways The ins and outs of reverse cholesterol transport.ABCA1 and atherosclerosis.Current understanding of the role of high-density lipoproteins in atherosclerosis and senescence.Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models.Genomic profiling in nuclear receptor-mediated toxicity.Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARalpha L162V polymorphism.Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation.Hepatic ABC transporters and triglyceride metabolism.ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis.Oxysterols trigger ABCA1-mediated basolateral surfactant efflux.Increased ABCA1 activity protects against atherosclerosis.Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts.Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux.The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides.Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly.Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets Intestinal ABCA1 directly contributes to HDL biogenesis in vivo LXR as a novel antithrombotic target Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions

P2860

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P2860

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

Item

http://www.wikidata.org/entity/Q40796761

description

2001 nî lūn-bûn

@nan

2001年の論文

@ja

2001年学术文章

@wuu

2001年学术文章

@zh-cn

2001年学术文章

@zh-hans

2001年学术文章

@zh-my

2001年学术文章

@zh-sg

2001年學術文章

@yue

2001年學術文章

@zh

2001年學術文章

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name

Human ABCA1 BAC transgenic mic ...... response elements in intron 1.

@en

type

Item

label

Human ABCA1 BAC transgenic mic ...... response elements in intron 1.

@en

prefLabel

Human ABCA1 BAC transgenic mic ...... response elements in intron 1.

@en

P1476

Human ABCA1 BAC transgenic mic ...... response elements in intron 1

@en

P2093

A Brooks-Wilson

http://www.w3.org/2001/XMLSchema#string

A Kwok

http://www.w3.org/2001/XMLSchema#string

B R Leavitt

http://www.w3.org/2001/XMLSchema#string

B Tan

http://www.w3.org/2001/XMLSchema#string

C Fievet

http://www.w3.org/2001/XMLSchema#string

C L Wellington

http://www.w3.org/2001/XMLSchema#string

E R James

http://www.w3.org/2001/XMLSchema#string

G Liu

http://www.w3.org/2001/XMLSchema#string

L H Zhang

http://www.w3.org/2001/XMLSchema#string

N Bissada

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

LXR, a nuclear receptor that defines a distinct retinoid response pathway

Correlation between protein and mRNA abundance in yeast

Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

P304

33969-33979

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scholarly article

P356

10.1074/JBC.M102503200

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

276

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Bart Staels

Michael R. Hayden

Roshni Singaraja

P577

2001-06-21T00:00:00Z

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P698

11423537

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Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

about

P2860

P2860

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

description

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698