IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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Children's Oncology Group's 2013 blueprint for research: bone tumorsDe novo motif identification improves the accuracy of predicting transcription factor binding sites in ChIP-Seq data analysis.Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group.High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibitionNew strategies in ewing sarcoma: lost in translation?Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro.R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axisOncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanismsLong noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphomaReprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma.Advances in sarcoma genomics and new therapeutic targets.Targeted therapy in Ewing sarcoma.BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia.The biology of ewing sarcomaRecent advances in the molecular pathogenesis of Ewing's sarcoma.Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma CellsA molecular function map of Ewing's sarcoma.Evaluation of Novel Targeted Therapies in Aggressive Biology Sarcoma Patients after progression from US FDA approved Therapies.BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cellsTargeted therapies in bone sarcomas: current approach and future directions.Modeling sarcomagenesis using multipotent mesenchymal stem cells.Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy.Ewing sarcoma: biology-based therapeutic perspectives.Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities.The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor.A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Prognostic and therapeutic relevance of the IGF pathway in Ewing's sarcoma patients.Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling.MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions.
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P2860
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
IGF1 is a common target gene o ...... mesenchymal progenitor cells.
@en
type
label
IGF1 is a common target gene o ...... mesenchymal progenitor cells.
@en
prefLabel
IGF1 is a common target gene o ...... mesenchymal progenitor cells.
@en
P2093
P2860
P1433
P1476
IGF1 is a common target gene o ...... n mesenchymal progenitor cells
@en
P2093
Domizio Suvà
Ivan Stamenkovic
Luisa Cironi
Mario-Luca Suvà
Natalie Wolf
Nicolò Riggi
Paolo Provero
P2860
P356
10.1371/JOURNAL.PONE.0002634
P407
P577
2008-07-09T00:00:00Z