The splicing factor U1C represses EWS/FLI-mediated transactivation
about
The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.RGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domainsThe RNA Splicing Response to DNA DamageTwenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic LandscapesMolecular mechanisms of ETS transcription factor-mediated tumorigenesisProtein disorder in the human diseasome: unfoldomics of human genetic diseases.Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblastsSmall-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.Biology of EWS/ETS fusions in Ewing's family tumors.Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis.Mechanisms of sarcoma development.Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte developmentEwing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.Molecular abnormalities in Ewing's sarcoma.Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities.Ewing sarcoma protein: a key player in human cancerRNA-binding proteins as molecular links between cancer and neurodegeneration.EWS/FLI alters 5'-splice site selection.Structure-function based molecular relationships in Ewing's sarcoma.Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins.Role of FET proteins in neurodegenerative disorders.Alternative splicing and cell survival: from tissue homeostasis to disease.Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Downstream EWS/FLI1 - upstream Ewing's sarcomaCAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells.EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice.Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription.DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.Erythroblast transformation by FLI-1 depends upon its specific DNA binding and transcriptional activation properties.
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P2860
The splicing factor U1C represses EWS/FLI-mediated transactivation
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The splicing factor U1C represses EWS/FLI-mediated transactivation
@ast
The splicing factor U1C represses EWS/FLI-mediated transactivation
@en
The splicing factor U1C represses EWS/FLI-mediated transactivation
@nl
type
label
The splicing factor U1C represses EWS/FLI-mediated transactivation
@ast
The splicing factor U1C represses EWS/FLI-mediated transactivation
@en
The splicing factor U1C represses EWS/FLI-mediated transactivation
@nl
prefLabel
The splicing factor U1C represses EWS/FLI-mediated transactivation
@ast
The splicing factor U1C represses EWS/FLI-mediated transactivation
@en
The splicing factor U1C represses EWS/FLI-mediated transactivation
@nl
P2860
P3181
P356
P1476
The splicing factor U1C represses EWS/FLI-mediated transactivation
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M001661200
P407
P577
2000-08-11T00:00:00Z