Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.
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Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor proteinA new view of carcinogenesis and an alternative approach to cancer therapyExpression profile of genes regulated by activity of the Na-H exchanger NHE1Cancer cell metabolism: implications for therapeutic targetsThe Na(+) /H(+) exchanger and pH regulation in the heartIon transporters in brain tumorsCofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide bindingExpression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchangerUpregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H⁺ extrusion, cell migration and survival.Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of human.NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulatorsAmiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts.Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewMetabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK).Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity).Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer questionBiological activities and molecular targets of the human papillomavirus E7 oncoprotein.Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen.Tumor metabolism, cancer cell transporters, and microenvironmental resistance.Sodium magnetic resonance imaging: from research to clinical use.Acidic stress promotes a glioma stem cell phenotype.Structure and function of the NHE1 isoform of the Na+/H+ exchanger.The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cellsIncreased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression.Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.Na(+)/H(+) exchange and hypoxic pulmonary hypertension.MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cellsMicroenvironmental and cellular consequences of altered blood flow in tumours.Epidermal growth factor activates Na(+/)H(+) exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin.Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel BindingIdentification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Intracellular pH as a determinant of vascular smooth muscle function.Therapeutic implications of targeting energy metabolism in breast cancer.Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1.
P2860
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P2860
Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Na+/H+ exchanger-dependent int ...... rmation-associated phenotypes.
@en
type
label
Na+/H+ exchanger-dependent int ...... rmation-associated phenotypes.
@en
prefLabel
Na+/H+ exchanger-dependent int ...... rmation-associated phenotypes.
@en
P2093
P50
P356
P1433
P1476
Na+/H+ exchanger-dependent int ...... ormation-associated phenotypes
@en
P2093
A Bellizzi
I Malanchi
M Alunni-Fabbroni
M Tommasino
V Albarani
P304
P356
10.1096/FJ.00-0029COM
P407
P577
2000-11-01T00:00:00Z