The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase.
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CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activityImpact of CDT Toxin on Human DiseasesBacterial Genotoxins: Merging the DNA Damage Response into Infection BiologyThe Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious ToxinThe Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.Effector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif.Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinomaCharacterization of cytolethal distending toxin of campylobacter species isolated from captive macaque monkeys.Breaking the Gingival Epithelial Barrier: Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease.Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol.Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin.Identification of the znuA-encoded periplasmic zinc transport protein of Haemophilus ducreyi.Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cellsTranscription of candidate virulence genes of Haemophilus ducreyi during infection of human volunteersExpression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers.Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systemsRecombinant Actinobacillus actinomycetemcomitans cytolethal distending toxin proteins are required to interact to inhibit human cell cycle progression and to stimulate human leukocyte cytokine synthesisImmunopathogenesis of Haemophilus ducreyi infection (chancroid)Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineagesExposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation.Functional studies of the recombinant subunits of a cytolethal distending holotoxin.Resistance of human periodontal ligament fibroblasts to the cytolethal distending toxin of Actinobacillus actinomycetemcomitans.Bacterial genotoxins promote inside-out integrin β1 activation, formation of focal adhesion complexes and cell spreading.Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cellsThe Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosisThe contribution of cytolethal distending toxin to bacterial pathogenesis.Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi.Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice.Contribution of Helicobacter hepaticus cytolethal distending toxin subunits to human epithelial cell cycle arrest and apoptotic death in vitroThe biology of the cytolethal distending toxinsOn the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis.Campylobacter jejuni cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells.Cellular internalization of cytolethal distending toxin from Haemophilus ducreyiHaemophilus ducreyi inhibits phagocytosis by U-937 cells, a human macrophage-like cell line.Cytolethal distending toxin demonstrates genotoxic activity in a yeast model.The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation.Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cellsDifferential effect of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans on co-cultures of human oral cells.The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.
P2860
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P2860
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
The cytolethal distending toxi ...... -cycle arrest in the G2 phase.
@en
type
label
The cytolethal distending toxi ...... -cycle arrest in the G2 phase.
@en
prefLabel
The cytolethal distending toxi ...... -cycle arrest in the G2 phase.
@en
P2093
P2860
P356
P1476
The cytolethal distending toxi ...... -cycle arrest in the G2 phase.
@en
P2093
E Chaves-Olarte
M Thelestam
T Lagergård
X Cortes-Bratti
P2860
P304
P356
10.1172/JCI3831
P407
P577
1999-01-01T00:00:00Z