Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. - Wikidata - awgldk - TriplyDB

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.

http://www.wikidata.org/entity/Q40881142

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Abstracts for the Thirteenth Annual Meeting of the Society for Neuro-Oncology Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells Cancerous stem cells can arise from pediatric brain tumors Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas In vivo models of primary brain tumors: pitfalls and perspectives.Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategies The potential origin of glioblastoma initiating cells MAPK pathway activation in pilocytic astrocytoma Will kinase inhibitors make it as glioblastoma drugs?Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma Contemporary murine models in preclinical astrocytoma drug development A drosophila model for EGFR-Ras and PI3K-dependent human glioma A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro RAS oncogenes: weaving a tumorigenic web Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone Versatility of RNA-Binding Proteins in Cancer Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion Cell of origin for malignant gliomas and its implication in therapeutic development Advances in the genetics of glioblastoma: are we reaching critical mass?PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis.Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data.Emerging role of new transgenic mouse models in glioma research.Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma.A reproducible brain tumour model established from human glioblastoma biopsies Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.

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P2860

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.

http://www.wikidata.org/entity/Q40881142

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Combined activation of Ras and ...... lioblastoma formation in mice.

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Celestino J

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Dai C

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Holland EC

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Sawaya RE

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Schaefer L

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P2860

Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.

The akt kinase: molecular determinants of oncogenicity

Signal transduction pathways and their relevance in human astrocytomas.

Proliferation of human malignant astrocytomas is dependent on Ras activation.

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