Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line.
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Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implicationsElectrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm.Clinical and pharmacological experience with LJP-394.Pharmacological treatment of the ion transport defect in cystic fibrosis.The block of CFTR by scorpion venom is state-dependentDual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.Potent stimulation and inhibition of the CFTR Cl(-) current by phloxine B.Pharmacological approaches to correcting the ion transport defect in cystic fibrosis.Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTRVoltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation.CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTRSynergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran.Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.A quantitative description of the activation and inhibition of CFTR by potentiators: Genistein.Modulation of cystic fibrosis transmembrane conductance regulator (CFTR) activity and genistein binding by cytosolic pH.Curcumin and genistein additively potentiate G551D-CFTR.Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum.Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channelPhloxine B interacts with the cystic fibrosis transmembrane conductance regulator at multiple sites to modulate channel activity.Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker.The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.Partial rescue of F508del-CFTR channel gating with modest improvement of protein processing, but not stability by a dual-acting small molecule.Structural mechanisms of CFTR function and dysfunction.
P2860
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P2860
Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line.
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2000 nî lūn-bûn
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name
Two mechanisms of genistein in ...... expressed in murine cell line.
@en
type
label
Two mechanisms of genistein in ...... expressed in murine cell line.
@en
prefLabel
Two mechanisms of genistein in ...... expressed in murine cell line.
@en
P2093
P2860
P921
P1476
Two mechanisms of genistein in ...... expressed in murine cell line.
@en
P2093
P2860
P304
P356
10.1111/J.1469-7793.2000.T01-1-00317.X
P407
P478
P577
2000-04-01T00:00:00Z