Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.
about
CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATEThe silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunctionObligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerizationImpact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Phosphorylation of CFTR by PKA promotes binding of the regulatory domainMutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingRevertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.CFTR channel pharmacology: novel pore blockers identified by high-throughput screening.Molecular modelling and molecular dynamics of CFTR.Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)).Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.Conformational changes in the catalytically inactive nucleotide-binding site of CFTR.Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.CLC-0 and CFTR: chloride channels evolved from transporters.Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterTargeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Cystic fibrosis transmembrane conductance regulator (ABCC7) structureAltering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel.The gating of the CFTR channel.Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate.N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel.Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics.Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore.
P2860
Q25256649-7BBCC7FA-D243-4C27-B8C7-66D5DAF6B1DAQ27674253-A2B1D51B-1091-467F-BF83-C5642A7D7416Q28658805-3B695598-5955-4699-B2A9-7C34A1314E07Q28829296-A9FE7AF1-6163-4EA1-A473-C67AC99B2818Q30372632-1F92558E-6A17-46AC-939A-5EF5C69801CBQ33671461-FD29B132-C7B8-4906-9EE7-A5864D36A34EQ33910924-86F89730-2F66-49C2-9D41-6A5827F5B3B3Q35018175-6DB41895-5354-4C76-8D52-62602B492C7AQ35215090-930E8B1B-0F30-4F73-9353-C783576B742AQ35234571-73F96B5E-7553-4FF2-B75B-58D64F6D2B04Q35847415-81406043-032B-4B92-B256-507D7FFEB379Q36158194-1F18AF80-BCBC-4A77-B7DB-EB2C70725B4BQ36295891-896DBA17-5E8F-45C8-9826-3CEB4902BC11Q36371798-3A1D1166-983A-48C2-B270-D71F71596BA4Q36412828-550C522E-E441-4E82-B6FB-FFBCB6EA53B3Q36951968-9113488A-EAAA-4EAF-9D97-07FDF64DCF05Q37080842-C1FAC9F4-0C01-4295-BCE0-504162992969Q37129332-349334C9-EBAF-41E7-92F1-4951B87391F9Q37234590-1BCDC685-5B74-4E3D-890B-7CA74E63E18FQ37836188-D347B4D4-7592-4EA3-88E9-E7E79C427573Q37885153-DE57A167-21A5-4A3A-A799-49325A5774AFQ38078917-D969424E-CC96-4A59-8710-09A444687869Q38805999-BDA690BA-D4D4-4BDC-BA13-40F62D07DE04Q38970505-A4863530-D6B4-4744-AF84-D61168C03844Q39647491-15AB76AC-881C-4476-872C-00C2ED3D1B24Q40008065-16A0D962-65FD-48DE-8A5E-13ACF288193FQ40347000-B14C72EA-5A64-4518-B37A-32F3056C05E8Q42416978-16DD4630-B49B-440C-ADE7-2E506523E5DAQ42622816-3844DD94-65E0-4C91-AD1F-E3AD79C1EBD9Q42861207-CB650486-F0C8-41A6-BA04-9ABDD5E41155Q47343534-366C645B-E3AD-4808-A6E3-E31500506FFCQ54211454-F2136A12-C696-4B78-A7F4-93B6E388581C
P2860
Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@ast
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@en
type
label
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@ast
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@en
prefLabel
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@ast
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@en
P2093
P2860
P356
P1476
Voltage-dependent gating of th ...... uctance regulator Cl- channel.
@en
P2093
David N Sheppard
Toby S Scott-Ward
Zhiwei Cai
P2860
P304
P356
10.1085/JGP.200308921
P577
2003-11-01T00:00:00Z