Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
about
The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell proteinHuman recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoproteinEndothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulumCharacterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitorsNeprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesA three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysinDynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities.Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assayAmyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearanceAutocrine regulation of human sperm motility by tachykinins.Reduced fertility in male mice deficient in the zinc metallopeptidase NL1Neprilysin-2 is an important β-amyloid degrading enzyme.Transcriptome profiling of the testis reveals genes involved in spermatogenesis and marker discovery in the oriental fruit fly, Bactrocera dorsalis.Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?Endothelin-3-converting enzyme activity of the KEL1 and KEL6 phenotypes of the Kell blood group system.In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity.Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function.
P2860
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P2860
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Molecular cloning and biochemi ...... dase of the neprilysin family.
@en
type
label
Molecular cloning and biochemi ...... dase of the neprilysin family.
@en
prefLabel
Molecular cloning and biochemi ...... dase of the neprilysin family.
@en
P2093
P2860
P1433
P1476
Molecular cloning and biochemi ...... dase of the neprilysin family.
@en
P2093
Carpentier M
Desgroseillers L
Marcinkiewicz M
P2860
P304
P356
10.1042/0264-6021:3470419
P407
P577
2000-04-01T00:00:00Z