Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
about
TIP120A associates with cullins and modulates ubiquitin ligase activityASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexesSuppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signalingThe E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationAn intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Principles of interleukin (IL)-6-type cytokine signalling and its regulationRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationGrit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter moleculesActivation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexTwo Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activitiesNegative regulation of cytokine signaling and immune responses by SOCS proteinsThe role of cullin 5-containing ubiquitin ligasesVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerThe role of suppressors of cytokine signalling in human neoplasmsSuppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signalSuppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signalingSuppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsThe SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoDynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.Negative regulation of receptor tyrosine kinase signals.Favorable prognostic value of SOCS2 and IGF-I in breast cancer.HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1)Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.The emerging role of the COP9 signalosome in cancer.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells.Regulation of cytokine receptor signaling by SOCS1.Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5α-induced inhibition of human immunodeficiency virus type-1 production.Are SOCS suppressors, regulators, and degraders?Oncogenic aberrations of cullin-dependent ubiquitin ligases.Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritisThe Role of Elongin BC-Containing Ubiquitin Ligases.The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.Negative regulation of FAK signaling by SOCS proteins.
P2860
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P2860
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
@en
type
label
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
@en
prefLabel
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
@en
P356
P1476
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
@en
P2093
S Ilangumaran
P304
14005-14008
P356
10.1074/JBC.C000106200
P407
P577
2000-05-01T00:00:00Z