Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
about
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionFunction, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblastsCytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth.ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment.Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning.Localization and function of cytosolic phospholipase A2alpha at the Golgi.Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles.A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolismPulmonary surfactant phosphatidylglycerol inhibits Mycoplasma pneumoniae-stimulated eicosanoid production from human and mouse macrophagesThiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregationBinding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.Production of prostaglandin E₂ in response to infection with modified vaccinia Ankara virusCYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5aDiscrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).Pathway-oriented profiling of lipid mediators in macrophages.Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha.Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesisModulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acidsGolgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins.Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010--present).Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta.Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.Arachidonic acid induces an increase of β-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells.Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts.Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophagesEffects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulumGroup IVA phospholipase A2 is necessary for the biogenesis of lipid droplets.
P2860
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P2860
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
@en
type
label
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
@en
prefLabel
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
@en
P2093
P356
P1476
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
@en
P2093
F Watanabe
H Hashizume
I Teshirogi
P304
P356
10.1021/JM9905155
P407
P577
2000-03-01T00:00:00Z