Arrestin binding to the M(2) muscarinic acetylcholine receptor is precluded by an inhibitory element in the third intracellular loop of the receptor.
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The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsAcidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestinsAgonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motifA dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin bindingLigand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.Peptides as receptor ligand drugs and their relationship to G-coupled signal transduction.G-protein-coupled receptor phosphorylation: where, when and by whom.Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responsesFew residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins.Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.The G protein-coupled receptors: pharmacogenetics and disease.Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms.Custom-designed proteins as novel therapeutic tools? The case of arrestins.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Structural determinants of arrestin functionsNon-neuronal functions of the m2 muscarinic acetylcholine receptor.The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.Multiple distant amino acid residues present in the serpentine region of the follitropin receptor modulate the rate of agonist-induced internalization.Targeting individual GPCRs with redesigned nonvisual arrestins.Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling.Axonal targeting of the 5-HT1B serotonin receptor relies on structure-specific constitutive activation.Molecular Mechanisms of GPCR Signaling: A Structural Perspective.
P2860
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P2860
Arrestin binding to the M(2) muscarinic acetylcholine receptor is precluded by an inhibitory element in the third intracellular loop of the receptor.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Arrestin binding to the M(2) m ...... cellular loop of the receptor.
@en
type
label
Arrestin binding to the M(2) m ...... cellular loop of the receptor.
@en
prefLabel
Arrestin binding to the M(2) m ...... cellular loop of the receptor.
@en
P2093
P2860
P356
P1476
Arrestin binding to the M(2) m ...... acellular loop of the receptor
@en
P2093
J A Ptasienski
R Pals-Rylaarsdam
P2860
P304
P356
10.1074/JBC.275.13.9284
P407
P577
2000-03-01T00:00:00Z