High level calcineurin activity predisposes neuronal cells to apoptosis.
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Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosisThe interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cellsDownregulation of calcineurin activity in cervical carcinomaThe cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risksTreatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activationTargeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death.Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathwayCalcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosisCyclophilin C-associated protein and cyclophilin C mRNA are upregulated in penumbral neurons and microglia after focal cerebral ischemiaA calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.Calcineurin links Ca2+ dysregulation with brain agingCalcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas.Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits.Myelin associated glycoprotein cross-linking triggers its partitioning into lipid rafts, specific signaling events and cytoskeletal rearrangements in oligodendrocytes.Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity.uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in gliomaClinical trials for cytoprotection in stroke.Over-expression of DSCR1 protects against post-ischemic neuronal injuryRas and rheb signaling in survival and cell deathCombined treatment with FK506 and nerve growth factor for spinal cord injury in rats.Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics.Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration.Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.Neuroimmunomodulation by calcineurin in aging and Alzheimer's disease.A role for calcineurin in Alzheimer's disease.Neurotoxicity of immunosuppressive therapies in organ transplantation.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.Central modulation of cyclosporine-induced hypertension.Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.Mitochondrial fission and fusion in secondary brain damage after CNS insults.Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampusRestless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure.Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.
P2860
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P2860
High level calcineurin activity predisposes neuronal cells to apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
High level calcineurin activity predisposes neuronal cells to apoptosis.
@en
type
label
High level calcineurin activity predisposes neuronal cells to apoptosis.
@en
prefLabel
High level calcineurin activity predisposes neuronal cells to apoptosis.
@en
P2093
P356
P1476
High level calcineurin activity predisposes neuronal cells to apoptosis.
@en
P2093
Shinoura N
P304
34450-34458
P356
10.1074/JBC.274.48.34450
P407
P577
1999-11-01T00:00:00Z