Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.
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Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidaseHuman neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutationDetection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidasesA 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activityTripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosphArachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase.Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".SH3-dependent assembly of the phagocyte NADPH oxidase.Cytosolic components of the respiratory burst oxidase: resolution of four components, two of which are missing in complementing types of chronic granulomatous diseasePhosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activationRequirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase.Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase CThe electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.Modulation of polymorphonuclear leukocyte microbicidal activity and oxidative metabolism by fibrinogen degradation products D and E.Platelet-derived growth factor stimulates phagocytosis and blocks agonist-induced activation of the neutrophil oxidative burst: a possible cellular mechanism to protect against oxygen radical damage.Modulation of the alveolar macrophage superoxide production by protein phosphorylation.Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease.Hypothesis: disseminated intravascular inflammation as the inflammatory counterpart to disseminated intravascular coagulation.NADPH-binding protein of the neutrophil superoxide-generating oxidase of guinea pigsCharacterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.Chronic granulomatous disease due to a defect in the cytosolic factor required for nicotinamide adenine dinucleotide phosphate oxidase activationThe NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen speciesActivation of the human neutrophil superoxide-generating oxidase: studies in a reconstituted subcellular system.Reactive oxygen species in phagocytic leukocytesRegulation of Nox and Duox enzymatic activity and expressionBiological roles for the NOX family NADPH oxidases.O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA.Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).Leukocytic oxygen activation and microbicidal oxidative toxins.The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase.The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.A phosphoprotein of Mr 47,000, defective in autosomal chronic granulomatous disease, copurifies with one of two soluble components required for NADPH:O2 oxidoreductase activity in human neutrophils.Functional defect in neutrophil cytosols from two patients with autosomal recessive cytochrome-positive chronic granulomatous disease.Activation of the leukocyte NADPH oxidase by protein kinase C in a partially recombinant cell-free system.Activation of human neutrophil NADPH oxidase by phosphatidic acid or diacylglycerol in a cell-free system. Activity of diacylglycerol is dependent on its conversion to phosphatidic acid.Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study.
P2860
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P2860
Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Activation of the respiratory ...... idence for a soluble cofactor.
@en
type
label
Activation of the respiratory ...... idence for a soluble cofactor.
@en
prefLabel
Activation of the respiratory ...... idence for a soluble cofactor.
@en
P2093
P2860
P356
P1476
Activation of the respiratory ...... idence for a soluble cofactor.
@en
P2093
C C Clayton
L C McPhail
P S Shirley
R Snyderman
P2860
P304
P356
10.1172/JCI111884
P407
P577
1985-05-01T00:00:00Z