Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. - Wikidata - awgldk - TriplyDB

Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.

Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.

http://www.wikidata.org/entity/Q40939852

about

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.A specific interface between integrin transmembrane helices and affinity for ligand Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins.Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis.Matrix-specific suppression of integrin activation in shear stress signaling.Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling Integrin-mediated adhesion regulates membrane order Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells.Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus.Quantitative analysis of platelet alpha v beta 3 binding to osteopontin using laser tweezers.Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent.Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets.Acidic extracellular pH promotes activation of integrin α(v)β(3).Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption.Integrin activation controls metastasis in human breast cancer Modulation of integrin activation by an entropic spring in the {beta}-knee Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress.Molecular pathway for cancer metastasis to bone.Mechanisms contributing to the activity of integrins on leukocytes.Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner.Integrin-targeted imaging of inflammation in vascular remodeling Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction Integrin signaling is critical for pathological angiogenesis Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3.The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells.Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins.General in vivo assay for the study of integrin cell membrane receptor microclustering.Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.

P2860

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P2860

Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.

http://www.wikidata.org/entity/Q40939852

description

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Aidoudi S

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Cheresh DA

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Hato T

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Nemerow GR

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Pampori N

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Shattil SJ

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Stupack DG

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P2860

Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding

Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail

Integrins: versatility, modulation, and signaling in cell adhesion

Integrins: emerging paradigms of signal transduction

Integrins take partners: cross-talk between integrins and other membrane receptors

Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells

Vitronectin and its receptors

Focal adhesions, contractility, and signaling

NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

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