Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.
about
Identification of a novel human Rad51 variant that promotes DNA strand exchangeGenetic Stabilization by p53 Involves Growth Regulatory and Repair PathwaysInvolvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)p53 in the DNA-Damage-Repair ProcessThe interaction of p53 with replication protein A mediates suppression of homologous recombinationGenetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.Manipulating the mammalian genome by homologous recombinationComparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.The p53 network in lung carcinogenesis.Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cellsThe complex interactions of p53 with target DNA: we learn as we go.p53 null fluorescent yellow direct repeat (FYDR) mice have normal levels of homologous recombinationp53 mediates senescence-like arrest induced by chronic replicational stressRadiation risk prediction and genetics: the influence of the TP53 gene in vivoAging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cellsRevisiting p53 for cancer-specific chemo- and radiotherapy: ten years after.Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein.p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway.DNA substrate dependence of p53-mediated regulation of double-strand break repair.An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms.Discriminatory suppression of homologous recombination by p53.p53 differentially inhibits cell growth depending on the mechanism of telomere maintenanceRole of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells.Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells.Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.Association of p53 and MSH2 with recombinative repair complexes during S phase.p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation.Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53.DNA damage response to the Mdm2 inhibitor nutlin-3.Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells.Wild-type p53 inhibits replication-associated homologous recombination.p53 protects from replication-associated DNA double-strand breaks in mammalian cells.p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.
P2860
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P2860
Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mutant p53 proteins stimulate ...... vity and of the G1 checkpoint.
@en
type
label
Mutant p53 proteins stimulate ...... vity and of the G1 checkpoint.
@en
prefLabel
Mutant p53 proteins stimulate ...... vity and of the G1 checkpoint.
@en
P2093
P2860
P356
P1433
P1476
Mutant p53 proteins stimulate ...... ivity and of the G1 checkpoint
@en
P2093
D Rouillard
Y Saintigny
P2860
P2888
P304
P356
10.1038/SJ.ONC.1202941
P407
P577
1999-06-01T00:00:00Z
P5875
P6179
1047547195