Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts.
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Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatmentRecent advances on tea polyphenolsA para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducerThe proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.Organic cadmium complexes as proteasome inhibitors and apoptosis inducers in human breast cancer cellsNew targets for the treatment of follicular lymphoma.Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors.Regulation of the G1 phase of the mammalian cell cycle.The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivoS-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.Proteasome inhibitors: from in vitro uses to clinical trials.p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future.Development of the proteasome inhibitor Velcade (Bortezomib).Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes.Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells.Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects.In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cellsOn the role of proteasomes in cell biology and proteasome inhibition as a novel frontier in the development of immunosuppressants.Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia.Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human isletsLactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivoIn vitro and in vivo antitumor activities and DNA binding mode of five coordinated cyclometalated organoplatinum(II) complexes containing biphosphine ligands.Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression.A review of the proteasome inhibitor bortezomib in multiple myeloma.Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibitionProteasome inhibition in hematologic malignancies.Green tea polyphenols as a natural tumour cell proteasome inhibitorInhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG.Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cellsThe ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.Update on treatment of follicular non-Hodgkin's lymphoma: focus on potential of bortezomib
P2860
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P2860
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Novel dipeptidyl proteasome in ...... not normal, human fibroblasts.
@en
type
label
Novel dipeptidyl proteasome in ...... not normal, human fibroblasts.
@en
prefLabel
Novel dipeptidyl proteasome in ...... not normal, human fibroblasts.
@en
P2093
P356
P1476
Novel dipeptidyl proteasome in ...... not normal, human fibroblasts.
@en
P2093
P2888
P304
P356
10.1038/SJ.CDD.4400436
P577
1998-12-01T00:00:00Z
P5875
P6179
1023998599