Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release. - Wikidata - awgldk - TriplyDB

Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.

Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.

http://www.wikidata.org/entity/Q41018696

about

Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein.Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling.Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor.Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors.Is the calcium receptor a molecular target for the actions of strontium on bone?Use of calcimimetics in uremic patients with secondary hyperparathyroidism: review.The calcium-sensing receptor and its interacting proteins.New concepts in calcium-sensing receptor pharmacology and signalling The calcium-sensing receptor: one of a kind.Calcium agonists in hyperparathyroidism.Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level Role of the calcium-sensing receptor in parathyroid gland physiology.No association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome.Stimulation of Ca2+-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney.The calcium-sensing receptor in normal physiology and pathophysiology: a review.Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy.Activation of the calcium-sensing receptor promotes apoptosis by modulating the JNK/p38 MAPK pathway in focal cerebral ischemia-reperfusion in mice Intracellular Ca2+ oscillations generated via the Ca2+-sensing receptor are mediated by negative feedback by PKCα at Thr888 Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.Gastric acid, calcium absorption, and their impact on bone health.The calcium sensing receptor: from calcium sensing to signaling.Gαi/o-dependent Ca(2+) mobilization and Gαq-dependent PKCα regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity.Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells.Increased receptor stimulation elicits differential calcium-sensing receptor(T888) dephosphorylation.Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor.Protein kinase C (PKC) phosphorylation of the Ca2+ o-sensing receptor (CaR) modulates functional interaction of G proteins with the CaR cytoplasmic tail.Amino acids and Ca2+ stimulate different patterns of Ca2+ oscillations through the Ca2+-sensing receptor.Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function Gα11 Mutation.The Expression of Calcium Sensing Receptor in Normal and Diabetic Rat Eyes.Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids.Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries.Identification of a functional Ca2+-sensing receptor in normal human gastric mucous epithelial cells.

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P2860

Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.

http://www.wikidata.org/entity/Q41018696

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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1998年论文

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1998年论文

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name

Protein kinase C phosphorylati ...... oupling to Ca2+ store release.

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type

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Protein kinase C phosphorylati ...... oupling to Ca2+ store release.

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prefLabel

Protein kinase C phosphorylati ...... oupling to Ca2+ store release.

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Journal of Biological Chemistry

P1476

Protein kinase C phosphorylati ...... oupling to Ca2+ store release.

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Bai M

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Brown EM

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Lane CR

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Quinn SJ

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Yang Y

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P2860

Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation

Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs

Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Multiple Range and Multiple F Tests

Rapid and efficient site-specific mutagenesis without phenotypic selection

Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor.

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

Familial hypocalciuric hypercalcemia associated with mutation in the human Ca(2+)-sensing receptor gene.

Markedly reduced activity of mutant calcium-sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

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21267-21275

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33

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9694886

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phosphorylation