The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells.
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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stressNck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translationA conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cellsAssociation of a protein phosphatase 1 activity with the human factor C1 (HCF) complexHuman BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functionsImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionGADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptorSynergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gammaA Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence.The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formationThe human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activityFeedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaInhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsHerpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to aotus nonhuman primates.APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cellsAlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha.Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18Herpesvirus vectors for therapy of brain tumors.Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expressionUp to four distinct polypeptides are produced from the γ34.5 open reading frame of herpes simplex virus 2Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.Signals that dictate nuclear, nucleolar, and cytoplasmic shuttling of the gamma(1)34.5 protein of herpes simplex virus type 1Dysregulation of autophagy in murine fibroblasts resistant to HSV-1 infectionViruses, endoplasmic reticulum stress, and interferon responses.A herpesvirus virulence factor inhibits dendritic cell maturation through protein phosphatase 1 and Ikappa B kinase.Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potentialp32 is a novel target for viral protein ICP34.5 of herpes simplex virus type 1 and facilitates viral nuclear egress.Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.Differential reliance on autophagy for protection from HSV encephalitis between newborns and adultsFunctional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1Replication of herpes simplex virus 1 depends on the gamma 134.5 functions that facilitate virus response to interferon and egress in the different stages of productive infection.Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.West Nile virus infection does not induce PKR activation in rodent cells.Neutralizing innate host defenses to control viral translation in HSV-1 infected cells.
P2860
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P2860
The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The gamma134.5 protein of herp ...... the enzyme in infected cells.
@en
type
label
The gamma134.5 protein of herp ...... the enzyme in infected cells.
@en
prefLabel
The gamma134.5 protein of herp ...... the enzyme in infected cells.
@en
P2860
P356
P1476
The gamma134.5 protein of herp ...... the enzyme in infected cells.
@en
P2860
P304
20737-20743
P356
10.1074/JBC.273.33.20737
P407
P577
1998-08-01T00:00:00Z