Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
about
The transcription factor p53: not a repressor, solely an activatorCathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesisThe requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-MAttenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell deathLysosomal proteins in cell death and autophagyDepletion of cathepsin D by transglutaminase 2 through protein cross-linking promotes cell survivalCathepsin D--many functions of one aspartic proteaseSphingosine-induced apoptosis is dependent on lysosomal proteasesRelocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy.Serial analysis of gene expression in mouse kidney following angiotensin II administration.Quantitative proteomic analysis reveals the perturbation of multiple cellular pathways in HL-60 cells induced by arsenite treatment.DAP kinase and DAP-3: novel positive mediators of apoptosisLysosomal destabilization in p53-induced apoptosisLysosomal involvement in apoptosis.Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role.Microarray gene expression analysis in atrophying rainbow trout muscle: a unique nonmammalian muscle degradation model.Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D.Destination 'lysosome': a target organelle for tumour cell killing?Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop.Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivityGlobal genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity.Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent mannerRedefining the p53 response element.Regulation of apoptosis-associated lysosomal membrane permeabilization.The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease.Serum Markers of Neurodegeneration in Maple Syrup Urine Disease.Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells.Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7.Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts.Characterization of the acetaminophen-induced degradation of cytochrome P450-3A4 and the proteolytic pathway.A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.IGFBP-3 mediates p53-induced apoptosis during serum starvation.Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line.Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.
P2860
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P2860
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
@en
type
label
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
@en
prefLabel
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
@en
P2093
P356
P1433
P1476
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1201755
P407
P577
1998-04-01T00:00:00Z
P5875
P6179
1043632183