The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.
about
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to NckPhosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationNovel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migrationConcerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityThe human phosphatase interactome: An intricate family portraitTyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factorsGab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathwaysInhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathwayRole of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activationDNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphataseShp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathwayGab1 is an integrator of cell death versus cell survival signals in oxidative stressHost adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents.A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein.Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal capsMolecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases.DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells.Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling.Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorCoordinated action of protein tyrosine phosphatases in insulin signal transduction.Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes.Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathwaySHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.Structure-based kinetic models of modular signaling protein function: focus on Shp2.Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
P2860
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P2860
The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The Shp-2 tyrosine phosphatase ...... gen-activated protein kinases.
@en
type
label
The Shp-2 tyrosine phosphatase ...... gen-activated protein kinases.
@en
prefLabel
The Shp-2 tyrosine phosphatase ...... gen-activated protein kinases.
@en
P2093
P2860
P356
P1476
The Shp-2 tyrosine phosphatase ...... gen-activated protein kinases.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.9.4904
P407
P577
1998-02-01T00:00:00Z