Association of CD8 with p56lck is required for early T cell signalling events.
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Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphataseMolecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influxDiscrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-lifeA dominant-negative transgene defines a role for p56lck in thymopoiesis.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Familial CD8 deficiency due to a mutation in the CD8 alpha gene.Evidence for differential intracellular signaling via CD4 and CD8 molecules.Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell.Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases.Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex.αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivityIdentification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.Genetic and immunochemical evidence for CD4-dependent association of p56lck with the alpha beta T-cell receptor (TCR): regulation of TCR-induced activation.Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevisHaemin enhancement of glucose transport in human lymphocytes: stimulation of protein tyrosine phosphatase and activation of p56lck tyrosine kinase.
P2860
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P2860
Association of CD8 with p56lck is required for early T cell signalling events.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Association of CD8 with p56lck is required for early T cell signalling events.
@en
type
label
Association of CD8 with p56lck is required for early T cell signalling events.
@en
prefLabel
Association of CD8 with p56lck is required for early T cell signalling events.
@en
P2093
P2860
P1433
P1476
Association of CD8 with p56lck is required for early T cell signalling events
@en
P2093
J A Ledbetter
N J Chalupny
P Kavathas
P2860
P304
P356
10.1002/J.1460-2075.1991.TB08061.X
P407
P577
1991-05-01T00:00:00Z