Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF
about
The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding siteHC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transductionMolecular dynamics simulations of the NGF-TrkA domain 5 complex and comparison with biological data.A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsyPresence of NGF and its receptor TrkA in degenerative lumbar facet joint specimens.An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae.Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and ChorioamnionitisIdentification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiationThe binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra.Comparison of nerve growth factor receptor binding models using heterodimeric muteins.Nerve growth factor: structure/function relationships.Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.Modeled structure of the 75-kDa neurotrophin receptor.Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part.
P2860
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P2860
Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Chimeric molecules with multip ...... specificities of NGF and BDNF
@en
type
label
Chimeric molecules with multip ...... specificities of NGF and BDNF
@en
prefLabel
Chimeric molecules with multip ...... specificities of NGF and BDNF
@en
P2093
P2860
P1433
P1476
Chimeric molecules with multip ...... specificities of NGF and BDNF
@en
P2093
P2860
P304
P407
P577
1991-08-01T00:00:00Z