Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.
about
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segmentsmRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' endPhysical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elementsClonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synoviumA deletion map of the human immunoglobulin heavy chain variable regionConservation of sequence in recombination signal sequence spacersImmunoglobulin genomics in the guinea pig (Cavia porcellus)A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana)Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding functionGenomic organization and sequences of immunoglobulin light chain genes in a primitive vertebrate suggest coevolution of immunoglobulin gene organization.Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire.Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses.Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotypeDetermination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis.Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell linesSegmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene regionPossible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genesBone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire.Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.The physical organization of the human immunoglobulin heavy chain gene complex.Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organDefining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.New roles for rheumatoid factor.Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable regionVariable region diversity in human circulating antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b. Preferential usage of two types of VH3 heavy chainsPopulation and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharideGerm line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ.Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesLimited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans.Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypesThe complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc
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P2860
Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Content and organization of th ...... nd linkage to the Ig CH locus.
@en
type
label
Content and organization of th ...... nd linkage to the Ig CH locus.
@en
prefLabel
Content and organization of th ...... nd linkage to the Ig CH locus.
@en
P2093
P2860
P1433
P1476
Content and organization of th ...... and linkage to the Ig CH locus
@en
P2093
C R Cantor
J E Berman
S J Mellis
P2860
P304
P356
10.1002/J.1460-2075.1988.TB02869.X
P407
P577
1988-03-01T00:00:00Z