The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
about
A role for ATR in the DNA damage-induced phosphorylation of p53Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complexA human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonucleaseIdentification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint genep110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytesHuman and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosisHus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damageHRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control geneATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutantsThe Schizosaccharomyces pombe rad3 checkpoint geneFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointhMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaksA human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damageTarget of rapamycin proteins and their kinase activities are required for meiosisSynaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein.Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choiceMammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathwayRecruitment of ATM protein to double strand DNA irradiated with ionizing radiationEpithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout miceBinding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunitTopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpointIdentification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouseMeiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanismsInfertility and aneuploidy in mice lacking a type IA DNA topoisomerase III betaMouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPaseCaspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene functionATR disruption leads to chromosomal fragmentation and early embryonic lethalityMeiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.In search of the tumour-suppressor functions of BRCA1 and BRCA2The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivoATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity.Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis.Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene.Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.Atm inactivation results in aberrant telomere clustering during meiotic prophase.
P2860
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P2860
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The Atr and Atm protein kinase ...... iotically pairing chromosomes.
@en
type
label
The Atr and Atm protein kinase ...... iotically pairing chromosomes.
@en
prefLabel
The Atr and Atm protein kinase ...... iotically pairing chromosomes.
@en
P2093
P356
P1433
P1476
The Atr and Atm protein kinase ...... eiotically pairing chromosomes
@en
P2093
D A Holtzman
E E Brainerd
E R Christenson
K S Keegan
M F Hoekstra
N J Bentley
P304
P356
10.1101/GAD.10.19.2423
P577
1996-10-01T00:00:00Z