The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.
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Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65)Hypoxic preconditioning differentially affects GABAergic and glutamatergic neuronal cells in the injured cerebellum of the neonatal ratCritical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memoryDistinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.Structural and functional analysis of cysteine residues in human glutamate decarboxylase 65 (GAD65) and GAD67.Presence of diabetes autoantigens in extracellular vesicles derived from human islets.Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clustersGABA expression and regulation by sensory experience in the developing visual systemDemonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesiclesCalpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission.Antigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons.Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsOverexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice.Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsyAdenosine A2A Receptor Gene Knockout Prevents l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia by Downregulation of Striatal GAD67 in 6-OHDA-Lesioned Parkinson's Mice.GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.GABAergic signalling in the immune system.Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and AutoimmunityIncreased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.New insights into the role of thyroid hormone in the CNS: the microglial track.Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.Differential effect of transient global ischaemia on the levels of γ-aminobutyric acid type A (GABA(A)) receptor subunit mRNAs in young and older rats.Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase.GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder.
P2860
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P2860
The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
The hydrophilic isoform of glu ...... brane-anchored isoform, GAD65.
@en
type
label
The hydrophilic isoform of glu ...... brane-anchored isoform, GAD65.
@en
prefLabel
The hydrophilic isoform of glu ...... brane-anchored isoform, GAD65.
@en
P2093
P2860
P356
P1476
The hydrophilic isoform of glu ...... brane-anchored isoform, GAD65.
@en
P2093
P2860
P304
37200-37209
P356
10.1074/JBC.274.52.37200
P407
P577
1999-12-01T00:00:00Z