Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
about
Slow, stochastic transgene repression with properties of a timerOncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingReceptor selection in B and T lymphocytes.Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappaB cell development in mice that lack one or both immunoglobulin kappa light chain genes.Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in transThe Igκ gene enhancers, E3' and Ed, are essential for triggering transcriptionDirect reprogramming of terminally differentiated mature B lymphocytes to pluripotency.Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificitiesA new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expressionTargeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance.Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells.Editing anti-DNA B cells by VlambdaxReceptor editing occurs frequently during normal B cell development.An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune systemDistinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.Allelic exclusion of immunoglobulin genes: models and mechanisms.Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes.Comparison of somatic mutation frequency among immunoglobulin genes.A human immunoglobulin lambda locus is similarly well expressed in mice and humans.
P2860
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P2860
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
@en
type
label
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
@en
prefLabel
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
@en
P2093
P2860
P1433
P1476
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model.
@en
P2093
P2860
P304
P407
P577
1990-02-01T00:00:00Z